NCIt definition : A bispecific antibody directed against both human epidermal growth factor receptor
(EGFR) and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential
immunostimulating and antineoplastic activities. Upon administration, dalmitamig binds
to both CD28 on cytotoxic T-lymphocytes (CTLs) and EGFR found on EGFR-expressing tumor
cells. This activates and redirects CTLs to EGFR-expressing tumor cells, which may
result in the CTL-mediated cell death of EGFR-expressing tumor cells. EGFR, a member
of the epidermal growth factor receptor family, is overexpressed on various tumor
cell types.;
Semantic type(s)