Dalmitamig - CISMeF

Preferred Label : Dalmitamig;

NCIt synonyms : EGFR x CD28 Bispecific Antibody REGN7075; Anti-EGFR/CD28 Bispecific Antibody REGN7075;

NCIt definition : A bispecific antibody directed against both human epidermal growth factor receptor (EGFR) and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration, dalmitamig binds to both CD28 on cytotoxic T-lymphocytes (CTLs) and EGFR found on EGFR-expressing tumor cells. This activates and redirects CTLs to EGFR-expressing tumor cells, which may result in the CTL-mediated cell death of EGFR-expressing tumor cells. EGFR, a member of the epidermal growth factor receptor family, is overexpressed on various tumor cell types.;

UNII : 02Z59O1UOM;

CAS number : 2765077-69-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2765077-69-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : REGN 7075; bsAb7075; REGN-7075;

NCI Metathesaurus CUI : CL1647930;

Details

Origin ID

C178284;

UMLS CUI

C5554919;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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