Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential

Preferred Label : Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential;

NCIt synonyms : Atypical Neurofibromatous Neoplasm with Uncertain Biologic Potential; AN; AN/ANUBP; Atypical Neurofibroma; ANUBP;

NCIt definition : A premalignant neurofibromatous neoplasm characterized by the presence of at least two of the following features: cytologic atypia, hypercellularity, less than 3 mitotic figures per 10 HPFs, and loss of neurofibroma architecture. It is associated with an increased risk of progression to malignant peripheral nerve sheath tumor.;

Neoplastic status : Uncertain Malignant Potential;

NCI Metathesaurus CUI : CL1647958;

Details

Origin ID

C178255;

UMLS CUI

C5552715;

Automatic exact mappings (from CISMeF team)
- Adenine [LOINC component]
- Atypical neurofibroma (morphologic abnormality) [SNOMED CT concept]
- adenine [MeSH Descriptor]
- atypical neurofibroma [DO Concept]
- electrodes [MeSH Descriptor]
Disease may have findings
- Cytologic Atypia [NCIt concept]
- Hypercellularity [NCIt concept]
- Low Mitotic Activity [NCIt concept]
Has associated anatomic sites
- Nervous System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell [NCIt concept]
- Neoplastic Perineural Cell [NCIt concept]
disease_has_finding
- Borderline Lesion [NCIt concept]
disease_has_normal_cell_origin
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
- Perineural Cell [NCIt concept]
disease_has_normal_tissue_origin
- Nerve Tissue and Nerve Sheaths [NCIt concept]
- Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths [NCIt concept]
disease_mapped_to_gene
- NF1 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- CDKN2A Gene Deletion [NCIt concept]
- CDKN2B Gene Deletion [NCIt concept]
- NF1 Gene Inactivation [NCIt concept]

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