Preferred Label : Anti-PLVAP CSR02-Fab-Tissue Factor;
NCIt synonyms : CSR02-Fab-TF;
NCIt definition : A recombinant protein consisting of an antigen-binding fragment (Fab) of CSR02, a
monoclonal antibody directed against plasmalemma vesicle associated protein (PLVAP),
and linked to human tissue factor (TF), with potential antineoplastic activity. Upon
intra-arterial (IA) infusion of CSR02-Fab-TF, the Fab moiety targets and binds to
the vascular endothelial cell specific protein PLVAP that is present on the blood
vessels of hepatocellular carcinoma (HCC) but that is not present on the blood vessels
of normal liver tissue. In turn, TF initiates the clotting cascade, thereby blocking
blood supply from the hepatic artery to the HCC. This deprives the HCC of its blood
supply and leads to tumor cell death.;
NCI Metathesaurus CUI : CL1647881;
Origin ID : C178219;
UMLS CUI : C5554872;
Semantic type(s)
- concept_is_in_subset
- has_target
