" /> Omapatrilat - CISMeF





Preferred Label : Omapatrilat;

NCIt synonyms : Omapatrilate; (4S,7S,10aS)-Octahydro-4-((S)-Alpha-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic Acid;

NCIt definition : A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP). ACE inhibition results in inhibition of the renin-angiotensin-aldosterone system thereby leading to the reduction of vasoconstriction. Inhibition of NEP leads to the inhibition of hydrolyzation of a number of endogenous vasoactive peptides, such as bradykinin and substance P and as NEP is the principal enzyme degrading natriuretic peptides, NEP inhibition also results in an increase in natriuretic peptidase circulation. Ultimately both effects result in blood vessel relaxation.;

UNII : 36NLI90E7T;

InChIKey : LVRLSYPNFFBYCZ-VGWMRTNUSA-N;

CAS number : 167305-00-2;

Drug name : Vanlev;

Molecule name : BMS-186716-01; BMS-186716;

Chemical formula : C19H24N2O4S2;

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11/05/2025


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