Preferred Label : MF59 Adjuvanted Molecular Clamp Stabilized SARS-CoV-2 Spike Protein Vaccine;
NCIt synonyms : MF59 Adjuvanted SARS-CoV-2 Sclamp Vaccine; MF59 Adjuvanted Molecular Clamp Stabilized SARS-CoV-2 SP Vaccine;
NCIt definition : A vaccine composed of a molecular clamp stabilized form of the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) spike protein (SP) combined with a squalene-based
vaccine adjuvant, MF59, with potential immunomodulating and anti-COVID-19 activities.
Upon administration of MF59 adjuvanted molecular clamp stabilized SARS-CoV-2 SP vaccine,
the SARS-CoV-2 SP activates the immune system to produce anti-SARS-CoV-2 SP antibodies
and T-cell responses against SARS-CoV-2 SP. The antibodies recognize the SP and kill
SARS-CoV-2. This prevents SARS-CoV-2 infection. SP, usually found on the surface of
SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.
The molecular clamp holds the SARS-CoV-2 SP in the otherwise unstable prefusion position,
which may generate a more robust antibody response. The adjuvant strongly stimulates
both T-cell and antibody immune responses when combined with the molecular clamp stabilized
SARS-CoV-2 SP.;
NCI Metathesaurus CUI : CL1647676;
Origin ID : C178139;
UMLS CUI : C5554860;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
