Preferred Label : SARS-CoV-2 mRNA Vaccine ARCT-021;
NCIt synonyms : ARCT-021 COVID-19 Vaccine; ARCT-021 SARS-CoV-2 Vaccine;
NCIt definition : A vaccine consisting of a lipid nanoparticle (LNP) encapsulating a self-transcribing
and replicating messenger RNA (mRNA) encoding the severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) prefusion spike glycoprotein (SP), with potential immunizing
and anti-COVID-19 activities. Upon administration of the SARS-CoV-2 mRNA vaccine ARCT-021,
the LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA
into the cells. The mRNA is then translated by the cellular protein translation machinery
to produce SARS-CoV-2 SP. This may activate both humoral and cellular immune responses,
and may provide active immunization against SARS-CoV-2 infection. SP, usually found
on the surface of SARS-CoV-2, plays an essential role in the infection pathway of
the SARS-CoV-2 virus.;
Molecule name : ARCT 021; ARCT-021;
NCI Metathesaurus CUI : CL1647661;
Origin ID : C178132;
UMLS CUI : C5554858;
Semantic type(s)
- concept_is_in_subset
