Preferred Label : Opnurasib;
NCIt synonyms : KRAS G12C Inhibitor JDQ443;
NCIt definition : An inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic
activity. Upon administration, opnurasib selectively targets the KRAS G12C mutant
and inhibits KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family
of oncogenes, serves an important role in cell signaling, division and differentiation.
Mutations of KRAS may induce constitutive signal transduction leading to tumor cell
growth, proliferation, invasion, and metastasis.;
UNII : Q3W0H3V1LQ;
CAS number : 2653994-08-0;
Molecule name : JDQ 443; JDQ-443; NVP-JDQ-443;
NCI Metathesaurus CUI : CL1647497;
Origin ID : C177916;
UMLS CUI : C5854863;
Semantic type(s)
- concept_is_in_subset
- has_target
