Preferred Label : CD3-activating CD19 Bi-specific Antibody A-319;
NCIt synonyms : Recombinant Anti-CD19/CD3 Antibody A-319;
NCIt definition : A recombinant T-cell activating bispecific antibody directed against the B-cell-specific
membrane protein CD19 and the CD3 antigen found on T-lymphocytes, with potential immunostimulating
and antineoplastic activities. Upon administration, CD3-activating CD19 bi-specific
antibody A-319 targets and binds to both the CD3 antigen on cytotoxic T-lymphocytes
(CTLs) and the CD19 antigen expressed on malignant B-cells. This activates and redirects
CTLs, bringing CD19-expressing tumor cells and CTLs together, and results in a CTL-mediated
immune response against CD19-expressing tumor cells. CD19 is a membrane antigen that
is widely expressed during B-cell development, from pro-B-cell to early plasma cell
stages.;
Molecule name : A 319; A-319;
NCI Metathesaurus CUI : CL1647591;
Origin ID : C177741;
UMLS CUI : C5554588;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
