SERPINE1/FOSB Fusion Gene

Preferred Label : SERPINE1/FOSB Fusion Gene;

NCIt synonyms : SERPINE1-FOSB Fusion Gene; Serpin Family E Member 1/FosB Proto-Oncogene Fusion Gene; Serpin Family E Member 1-FosB Proto-Oncogene Fusion Gene; SERPINE1::FOSB Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(7;19)(q22;q13) which fuses non-coding exon 1 of the SERPINE1 gene with exon 1 or 2 of the FOSB gene. This rearrangement is associated with pseudomyogenic hemangioendothelioma and expression of this fusion gene results in overexpression of protein FosB.;

NCI Metathesaurus CUI : CL1643451;

Details

Origin ID

C177672;

UMLS CUI

C5447934;

Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_has_abnormality
- t(7;19)(q22;q13) [NCIt concept]
gene_involved_in_molecular_abnormality
- t(7;19)(q22;q13) [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Pseudomyogenic Hemangioendothelioma [NCIt concept]
gene_mapped_to_disease
- Childhood Pseudomyogenic Hemangioendothelioma [NCIt concept]
- Pseudomyogenic Hemangioendothelioma [NCIt concept]
related_to_genetic_biomarker
- FOSB Gene [NCIt concept]
- SERPINE1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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