Preferred Label : Nanoplexed Poly I:C BO-112;
NCIt synonyms : Nanoplexed Poly IC BO-112; Nanoplexed Polyinosinic:Polycytidylic Acid BO-112;
NCIt definition : A synthetic double-stranded RNA (dsRNA) polyinosinic:polycytidylic acid (poly I:C)
nanoplexed with the cationic carrier polyethylenimine (PEI), with potential immunostimulating
and antineoplastic activities. Upon intratumoral administration, nanoplexed poly I:C
BO-112, which mimics viral RNAs, may stimulate the release of cytotoxic cytokines
and induces interferon-gamma production. This may increase the tumoricidal activities
of various immunohematopoietic cells. The PEI carrier enhances the delivery of the
agent into the cells.;
Molecule name : BO-112; BO 112;
NCI Metathesaurus CUI : CL1643313;
Origin ID : C177439;
UMLS CUI : C4733518;
Semantic type(s)
- concept_is_in_subset
