NCIt definition : A human immunoglobulin G4 (IgG4) monoclonal antibody directed against the immunosuppressive
protein galectin-9, with potential immunostimulating and antineoplastic activities.
Upon administration, the anti-galectin-9 monoclonal antibody LYT-200 targets, binds
to and blocks galectin-9 on tumor cells which prevents galectin-9-mediated signaling.
This may abrogate activation of immunosuppressive signaling pathways in the tumor
microenvironment (TME) and may activate a cytotoxic T-lymphocyte (CTL)-mediated immune
response against the galectin-9-expressing tumor cells. Galectin-9, overexpressed
on a variety of tumor cells, plays a key role in cancer cell proliferation and evasion
of immune responses. Its expression is correlated with decreased patient survival.;
Semantic type(s)