Preferred Label : Gorilla-derived Adenovirus-expressing HPV-6/11 Vaccine PRGN-2012;
NCIt synonyms : Therapeutic Cancer Vaccine PRGN-2012;
NCIt definition : An off-the-shelf (OTS) cancer vaccine comprised of a genetically engineered, replication-deficient
gorilla-derived adenovirus encoding human papillomavirus (HPV) types 6 and 11, with
potential immunostimulating and antineoplastic activities. Upon administration of
gorilla-derived adenovirus-expressing HPV-6/11 vaccine PRGN-2012, the adenovirus infects
and expresses the HPV-6/11 proteins. The expressed proteins stimulate the host immune
system to produce antigen-specific neutralizing antibodies and to mount a cytotoxic
T-lymphocyte (CTL) response against cells infected with HPV-6/11, thereby inducing
tumor cell lysis. HPV6/11 play a key role in the development of recurrent respiratory
papillomatosis (RRP).;
Molecule name : PRGN-2012; PRGN 2012;
NCI Metathesaurus CUI : CL1643054;
Origin ID : C177305;
UMLS CUI : C5447682;
Semantic type(s)
- concept_is_in_subset
- has_target
