Preferred Label : Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101;
NCIt synonyms : UCB-derived CD16-expressing NK Cells AB-101; NK Cells AB-101;
NCIt related terms : AB-101;
NCIt definition : A preparation of allogeneic, off-the-shelf natural killer (NK) cells, derived from
umbilical cord blood (UCB) and ex vivo-expanded, that expresses a high-affinity variant
of CD16, with potential immunostimulatory and antineoplastic activities. Upon administration,
UCB-derived CD16-expressing NK cells AB-101 lyse tumor cells. NK cells AB-101 also
secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response.
Upon coadministration with tumor-targeting monoclonal antibodies, the Fab moiety of
the antibodies bind to the tumor-associated antigens (TAAs) expressed on tumor cells
and the Fc moiety of the antibodies bind to CD16 expressed on NK cells AB-101. This
leads to NK cell activation, cytokine secretion and antibody-dependent cellular cytotoxicity
(ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface
of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating
ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor
immune response.;
UNII : EH13UJP078;
Molecule name : AB-101; AB 101;
NCI Metathesaurus CUI : CL1643101;
Origin ID : C177152;
UMLS CUI : C5447599;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
