Preferred Label : Ganulameran;
NCIt synonyms : BNT162b3 COVID-19 Vaccine; BNT162b3 SARS-CoV-2 Vaccine;
NCIt definition : A formulation consisting of lipid nanoparticle (LNP) encapsulating a nucleoside modified
messenger RNA (modRNA) encoding an optimized form of the full-length severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential
immunizing and anti-COVID-19 activities. Upon injection of ganulameran, the LNPs bind
to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into the cell.
The mRNA is then translated by the cellular protein translation machinery to produce
SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody and T-cell-mediated
immune response. This may provide active immunization against SARS-CoV-2 infection.
SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection
pathway of the SARS-CoV-2 virus.;
UNII : I74C16KK3J;
CAS number : 2433844-55-2;
Molecule name : BNT 162b3; BNT-162b3;
NCI Metathesaurus CUI : CL1642807;
Origin ID : C177085;
UMLS CUI : C5447574;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
