Preferred Label : Goflikicept;
NCIt definition : A heterodimeric fusion protein comprised of the extracellular portions of human interleukin
(IL)-1 receptor type 1 (IL-1R1) and IL-1 receptor accessory protein (IL-1RAcP) linked
to a mutant Fc portion of human immunoglobulin G1 (IgG1), with potential anti-inflammatory
activity. Upon administration, goflikicept targets and binds to the proinflammatory
cytokine IL-1 beta (IL-1b) and prevents the binding of IL-1b to the IL-1 receptor.
This inhibits IL-1b-mediated signaling pathways, and suppresses inflammatory responses
mediated by IL-1b. IL-1b plays a key role in inflammation, which is present in various
disease states.;
UNII : 11DRN01OK2;
CAS number : 2416984-26-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2416984-26-2
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G-SRS /a ;
Molecule name : RPH 104; RPH-104;
NCI Metathesaurus CUI : CL1642839;
Origin ID : C177057;
UMLS CUI : C5432265;
Semantic type(s)
- concept_is_in_subset
