Preferred Label : CD200 Activation Receptor Ligand hP1A8;
NCIt synonyms : CD200AR-L hP1A8;
NCIt definition : A humanized peptide ligand of the CD200 activation receptors (CD200ARs), with potential
immunostimulating and antineoplastic activities. Upon administration, CD200 activation
receptor ligand (CD200AR-L) human P1A8 (hP1A8) targets and binds to CD200ARs complexes
on antigen-presenting cells (APCs). This promotes immature dendritic cell (DC) differentiation
and cytokine production, and induces a T-cell-mediated immune response against tumor
cells. In addition, hP1A8 downregulates the expression of the inhibitory CD200 and
PD-1 receptors on APCs and T-cells. This inhibits CD200- and PD-1-mediated immunosuppression.
CD200, a type 1a transmembrane protein related to the B7 family of co-stimulatory
receptors, functions as an immune checkpoint that modulates immune responses through
an inhibitory receptor CD200 receptor 1 (CD200R1) and several activation receptors
(CD200ARs). It plays an important role in tumor evasion from host immunity.;
Molecule name : hP1A8;
NCI Metathesaurus CUI : CL1642836;
Origin ID : C177006;
UMLS CUI : C5447553;
Semantic type(s)
- concept_is_in_subset
