Fluorine F 18 3F-PHPG

Preferred Label : Fluorine F 18 3F-PHPG;

NCIt synonyms : [18F]3F-PHPG; 3-[18F]Fluoro-para-hydroxyphenethylguanidine;

NCIt definition : A radioconjugate containing a substrate of the norepinephrine transporter (NET), chromaffin granule amine transporter (CGAT; vesicular monoamine transporter 1; VMAT1; VAT1; solute carrier family 18 member 1; SLC18A1) and synaptic vesicular amine transporter (SVAT; vesicular monoamine transporter 2; VMAT2; VAT2; solute carrier family 18 member 2; SLC18A2) labeled with the positron-emitting radioisotope fluorine F 18, with potential diagnostic imaging applications upon positron emitting tomography (PET)/computed tomography (CT). Upon administration, fluorine F 18 3F-PHPG is taken up by NET, VMAT1 and VMAT2 and accumulates in adrenergic tissues. This may allow for the visualization of tumors expressing these transporters upon PET/CT. NET, VMAT1 and/or VMAT2 are expressed in some adrenergic tumors.;

NCI Metathesaurus CUI : CL1642781;

Details

Origin ID

C176982;

UMLS CUI

C5447533;

Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Chromaffin Granule Amine Transporter [NCIt concept]
- Sodium-Dependent Noradrenaline Transporter [NCIt concept]
- Synaptic Vesicular Amine Transporter [NCIt concept]

Keyword's position in hierarchy(ies) :

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