NCIt definition : A fusion gene resulting from a chromosomal translocation that fuses a PAX family gene
(usually PAX3 or PAX7, on chromosome 2 or 1, respectively) with the FOXO1 gene on
chromosome 13. These rearrangements result in expression of fusion proteins consisting
of the intact PAX family N-terminal DNA binding domain fused in-framed to the intact
FOXO1 C-terminal transcriptional activation domain and are associated with alveolar
rhabdomyosarcoma.;
Semantic type(s)