Preferred Label : Microbiome-derived Peptide Vaccine EO2463;
NCIt synonyms : Microbial-Derived Peptide Therapeutic Vaccine EO2463; Cancer Vaccine EO2463; Microbial-derived Peptide Vaccine EO2463;
NCIt definition : A microbiome therapeutic cancer peptide vaccine composed of onco-mimics, immunogenic
microbiome-derived peptides that are highly homologous to specific tumor-associated
antigens (TAAs), that are obtained and selected from the human gut microbiome, with
potential immunomodulating and antineoplastic activities. The microbiome-derived bacterial
antigens in EO2463 mimic TAAs that are highly expressed by malignant B-cells. Upon
administration of microbiome-derived peptide vaccine EO2463, the peptides are taken
up by and presented on dendritic cells (DCs) to T-cells. As the presented antigens
display molecular mimicry with selected TAAs on malignant B-cells, a memory T-cell-
and cytotoxic T-lymphocyte (CTL)-mediated immune response may be mounted against the
TAAs expressed on the malignant B-cells, thereby eradicating the cancer cells.;
Molecule name : EO-2463; EO 2463;
NCI Metathesaurus CUI : CL1642804;
Origin ID : C176953;
UMLS CUI : C5447512;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
