NCIt definition : The hydrochloride salt form of poziotinib, an orally bioavailable, quinazoline-based,
irreversible pan-epidermal growth factor receptor (EGFR or HER) inhibitor, with potential
antineoplastic activity. Upon oral administration, poziotinib inhibits EGFR (HER1
or ErbB1), HER2 and HER4, thereby inhibiting proliferation of tumor cells in which
these receptors are overexpressed and/or mutated. EGFRs, cell surface receptor tyrosine
kinases upregulated or mutated in a variety of cancer cell types, play key roles in
cellular proliferation and survival.;
Semantic type(s)