Preferred Label : Zimistobart;
NCIt synonyms : BMS 986315; Anti-NKG2A Monoclonal Antibody BMS-986315;
NCIt definition : A human monoclonal antibody against the human natural killer (NK) and T-lymphocyte
cell checkpoint inhibitor killer cell lectin-like receptor subfamily C member 1 (NKG2A),
with potential antineoplastic activity. Upon administration, zimistobart targets and
binds to NKG2A, and prevents the binding of NKG2A to its ligand human leukocyte antigen-E
(HLA-E), which is overexpressed on tumor cells. This blocks the HLA-E-mediated inhibition
of NKG2A-positive infiltrating NK and cytotoxic T-lymphocytes (CTLs) and induces a
NK and CTL-mediated immune response against the cancer cells leading to their destruction.
Human NKG2A, an inhibitory cell surface receptor covalently bound to CD94, is expressed
by NK cells and CTLs. Stimulation of the CD94/NKG2A complex inhibits the cytotoxic
activity of these cells. HLA-E, a nonclassical HLA class Ib molecule, is often overexpressed
on tumor cells and is associated with poor prognosis.;
UNII : C41SJ1JYR1;
CAS number : 2829290-06-2;
Molecule name : BMS-986315;
NCI Metathesaurus CUI : CL1642924;
Origin ID : C176867;
UMLS CUI : C5447481;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
