Preferred Label : YAP1 Antisense Oligonucleotide ION537;
NCIt synonyms : YAP1 ASO ION537;
NCIt definition : An antisense oligonucleotide (ASO) targeting the transcription coactivator yes-associated
protein 1 (YAP1), with potential antineoplastic activity. Upon administration, YAP1
ASO ION537 targets and binds to messenger RNA (mRNA) for YAP1, thereby inhibiting
translation of YAP1. Suppression of YAP1 expression prevents the binding of YAP1 to
transcription factors, thereby inhibiting gene transcription involved in tumor cell
proliferation and survival. The Hippo/YAP1 pathway is dysregulated in certain cancers,
resulting in constitutive YAP1 activation.;
Molecule name : ION 537; ION-537;
NCI Metathesaurus CUI : CL1642612;
Origin ID : C176846;
UMLS CUI : C5447467;
Semantic type(s)
- concept_is_in_subset
- has_target
