Preferred Label : Recombinant Newcastle Disease Virus-encoding Interleukin-12 MEDI9253;
NCIt synonyms : Recombinant NDV-encoding IL-12 MEDI9253;
NCIt definition : An oncolytic viral agent containing the oncolytic, live-attenuated, replication-competent
strain of the avian paramyxovirus Newcastle disease virus (NDV) that has been engineered
to include a transgene encoding the human pro-inflammatory cytokine interleukin-12
(IL-12), with potential antineoplastic and immunostimulating activities. Upon administration,
recombinant NDV-encoding IL-12 MEDI9253 specifically infects and replicates in cancer
cells. This may result in a direct cytotoxic effect involving the lysis of tumor cells
via apoptotic mechanisms and may eventually lead to an inhibition of cancer cell proliferation.
The production and secretion of IL-12 may potentiate and strengthen the anti-tumor
immune response and activates the immune system by promoting the activation of natural
killer cells (NK cells), inducing secretion of interferon-gamma and promoting cytotoxic
T-cell responses against tumor cells.;
Molecule name : MEDI-9253; MEDI 9253;
NCI Metathesaurus CUI : CL1642600;
Origin ID : C176843;
UMLS CUI : C5447466;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
