Preferred Label : Noraramtide;
NCIt synonyms : ARM KP1237; CD38-ARM KP1237; CD38-targeting ARM KP1237; CD38-targeting Antibody Redirecting Molecule KP1237; CD38-targeting Antibody Recruiting Molecule KP1237;
NCIt definition : A synthetic, small, bispecific antibody-redirecting/recruiting molecule (ARM) that
recognizes the tumor-associated antigen (TAA) and cell surface glycoprotein CD38 on
tumor cells with its target binding terminus (TBT) and, through connection by a tunable
linker domain, recognizes endogenous antibodies already present in the patient's blood
with its universal antibody binding terminus (uABT), with potential immunomodulating
and antineoplastic activities. Upon administration, noraramtide simultaneously targets
and binds to CD38 expressed on tumor cells with its TBT and to endogenous antibodies
with its uABT. This recruits immune effector cells, such as the patient's activated
natural killer (NK) cells, to eliminate the CD38-expressing tumor cells through antitumoral
antibody-dependent cellular cytotoxicity (ADCC). CD38, a type II transmembrane glycoprotein,
is present on various immune cells and hematologic malignancies. Its expression has
been correlated with poor prognosis.;
UNII : 7YQ5294J86;
CAS number : 2580150-96-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2580150-96-3
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : KP-1237; KP 1237; BHV 1100; BHV-1100;
NCI Metathesaurus CUI : CL1642597;
Origin ID : C176834;
UMLS CUI : C5447459;
Semantic type(s)
- concept_is_in_subset
- has_target
