Preferred Label : Porcupine Inhibitor Wnt-C59;
NCIt synonyms : Wnt Inhibitor Wnt-C59; PORCN Inhibitor Wnt-C59;
NCIt definition : An orally bioavailable inhibitor of porcupine (PORCN), with potential antineoplastic
activity. Upon oral administration, PORCN inhibitor Wnt-C59 specifically targets,
binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational
acylation of Wnt ligands and inhibits their secretion. This prevents the activation
of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in
Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required
for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion
and activity. Wnt signaling is dysregulated in a variety of cancers.;
CAS number : 1243243-89-1;
Molecule name : Wnt C59; C59; Wnt-C59;
NCI Metathesaurus CUI : CL1642614;
Origin ID : C176794;
UMLS CUI : C3661165;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
