Preferred Label : Tempol-containing MBM-02;
NCIt definition : An orally bioavailable gelatin capsule-based formulation containing tempol, a hydrophilic
piperidine nitroxide, with potential chemo/radioprotective and antioxidant activities.
Upon oral administration of MBM-02, tempol, being a free radical compound, may be
able to protect cells against the damaging effects of reactive oxygen species (ROS),
upon exposure to ionizing radiation and oxidative stress. MBM-02 may selectively protect
normal tissue from chemotherapy- and radiation-induced toxicities. Tempol is in its
protective form in oxygenated cells and is in its unprotective form in the hypoxic
tumor microenvironment (TME).;
Molecule name : MBM 02; MBM-02;
NCI Metathesaurus CUI : CL1642556;
Origin ID : C176779;
UMLS CUI : C5447434;
Semantic type(s)
- concept_is_in_subset
