Preferred Label : Gallium Ga 68 NODAGA-LM3;
NCIt synonyms : Gallium-68 Labeled LM3; 68Ga-NODAGA-p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH(2); 68Ga-1,4,7-triazacyclononane, 1-Glutaric Acid-4,7-acetic Acid-LM3; (68)Ga-NODAGA-LM3;
NCIt definition : A radiopharmaceutical agent comprised of LM3, a human somatostatin receptor (SSTR)
antagonist, chelated with 1,4,7-triazacyclononane,1-glutaric acid-4,7 acetic acid
(NODAGA) and radiolabeled with gallium Ga 68, that may be used as an imaging agent
for SSTR-expressing tumor cells upon positron emission tomography (PET). Upon administration
of gallium Ga 68 NODAGA-LM3, the LM3 moiety targets and binds to SSTRs that are present
on the cell membranes of many types of neuroendocrine tumors (NETs). This allows for
visualization of SSTR-positive cells upon PET imaging. SSTRs have been shown to be
present in large numbers on NETs and their metastases, while most other normal tissues
express low levels of SSTRs.;
NCI Metathesaurus CUI : CL1642562;
Origin ID : C176773;
UMLS CUI : C5447429;
Semantic type(s)
- concept_is_in_subset
