Preferred Label : IDH2 Mutant Inhibitor TQB3455;
NCIt synonyms : Isocitrate Dehydrogenase Type 2 Mutant Inhibitor TQB3455;
NCIt definition : An orally bioavailable inhibitor of mutated mitochondrial enzyme isocitrate dehydrogenase
type 2 (IDH2; IDH-2), with potential antineoplastic activity. Upon oral administration,
IDH2 mutant inhibitor TQB3455 specifically inhibits mutated IDH2, thereby inhibiting
the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate
(a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular
differentiation and an inhibition of cellular proliferation in tumor cells expressing
mutated IDH2. IDH2 is mutated in a variety of cancers, and mutated IDH2 initiate and
drive cancer growth by catalyzing the formation of 2HG and blocking cell differentiation.;
Molecule name : TQB 3455; TQB-3455;
NCI Metathesaurus CUI : CL1642553;
Origin ID : C176768;
UMLS CUI : C5447424;
Semantic type(s)
- concept_is_in_subset
