Preferred Label : Sturlimogene Erparepvec;
NCIt synonyms : Oncolytic HSV-1 Expressing Anti-CTLA-4 Antibody-like Molecule/GM-CSF RP2; Oncolytic Herpes Simplex Virus-1 Expressing Anti-CTLA-4 Antibody-like Molecule/GM-CSF
RP2; Oncolytic Virus RP2; Oncolytic HSV-1 Expressing Anti-CTLA-4 Antibody-like Molecule and GM-CSF RP2; Oncolytic Herpes Simplex Virus-1 Expressing Anti-CTLA-4 Antibody-like Molecule and
GM-CSF RP2;
NCIt definition : A genetically modified oncolytic viral strain of the herpes simplex type 1 (HSV-1)
virus, expressing the immunostimulatory cytokine granulocyte-macrophage colony-stimulating
factor (GM-CSF) and an antibody-like molecule directed against the human inhibitory
T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4;CTLA4),
with potential oncolytic, immunostimulating and antineoplastic activities. Upon administration,
sturlimogene erparepvec specifically infects and replicates in tumor cells causing
viral-mediated tumor cell lysis. The released virus particles, in turn, infect and
replicate in neighboring tumor cells. Tumor antigens released from the lysed tumor
cells also activate the immune system to induce a tumor-specific systemic immune and
cytotoxic T-lymphocyte (CTL) response, thereby killing nearby non-infected tumor cells.
Sturlimogene erparepvec expresses a fusogenic protein, GALV-GP R-, for optimal tumor
cell infection and killing. In addition, this agent promotes the secretion of GM-CSF
and anti-CTLA-4 antibody-like molecule by the tumor cells. GM-CSF attracts dendritic
cells (DCs) and may further stimulate a CTL-mediated immune response against tumor
cells. Anti-CTLA-4 antibody-like molecule targets and binds to CTLA-4 expressed on
T-cells, and inhibits the CTLA-4-mediated downregulation of T-cell activation. This
leads to a CTL-mediated immune response against tumor cells. CTLA-4, an inhibitory
receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in
the downregulation of the immune system.;
UNII : 53Z5E7R5KD;
CAS number : 2773482-44-1;
Molecule name : RP-2; RP 2;
NCI Metathesaurus CUI : CL1642740;
Origin ID : C176748;
UMLS CUI : C5444030;
Semantic type(s)
- concept_is_in_subset
