Preferred Label : Oncolytic Herpes Simplex Virus-1 Expressing Anti-CTLA-4 Antibody-like Molecule and
GM-CSF RP2;
NCIt synonyms : Oncolytic HSV-1 Expressing Anti-CTLA-4 Antibody-like Molecule/GM-CSF RP2; Oncolytic Herpes Simplex Virus-1 Expressing Anti-CTLA-4 Antibody-like Molecule/GM-CSF
RP2; Oncolytic Virus RP2; Oncolytic HSV-1 Expressing Anti-CTLA-4 Antibody-like Molecule and GM-CSF RP2;
NCIt definition : A genetically modified oncolytic viral strain of the herpes simplex type 1 (HSV-1)
virus, expressing the immunostimulatory cytokine granulocyte-macrophage colony-stimulating
factor (GM-CSF) and an antibody-like molecule directed against the human inhibitory
T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4;CTLA4),
with potential oncolytic, immunostimulating and antineoplastic activities. Upon administration,
the oncolytic HSV-1 expressing anti-CTLA-4 antibody-like molecule and GM-CSF RP2 specifically
infects and replicates in tumor cells causing viral-mediated tumor cell lysis. The
released virus particles, in turn, infect and replicate in neighboring tumor cells.
Tumor antigens released from the lysed tumor cells also activate the immune system
to induce a tumor-specific systemic immune and cytotoxic T-lymphocyte (CTL) response,
thereby killing nearby non-infected tumor cells. Oncolytic virus RP2 expresses a fusogenic
protein, GALV-GP R-, for optimal tumor cell infection and killing. In addition, Oncolytic
virus RP2 promotes the secretion of GM-CSF and anti-CTLA-4 antibody-like molecule
by the tumor cells. GM-CSF attracts dendritic cells (DCs) and may further stimulate
a CTL-mediated immune response against tumor cells. Anti-CTLA-4 antibody-like molecule
targets and binds to CTLA-4 expressed on T-cells, and inhibits the CTLA-4-mediated
downregulation of T-cell activation. This leads to a CTL-mediated immune response
against tumor cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin
superfamily (IgSF), plays a key role in the downregulation of the immune system.;
Molecule name : RP-2; RP 2;
NCI Metathesaurus CUI : CL1642740;
Origin ID : C176748;
UMLS CUI : C5444030;
Semantic type(s)
- concept_is_in_subset
