Preferred Label : IKKb-matured RNA-loaded Autologous Dendritic Cells DCIKKb;
NCIt synonyms : IKKb-matured RNA-loaded Autologous DCs DCIKKb; DCIKKb;
NCIt definition : A cancer vaccine consisting of autologous, monocyte-derived dendritic cells (DCs)
that are matured with tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1)
beta, IL-6, prostaglandin E2 (PGE2) and IkB kinase b (IKKb), and loaded by electroporation
with autologous total tumor RNA (TTRNA), RNA coding for tumor-associated antigens
(TAAs) that may include gp100, tyrosinase, PRAME, MAGE-A3 and/or IDO, and RNA coding
for driver mutations that may include GNAQ/GNA11Q209, R183, SF3B1R625, CYSLTR2L129Q
and/or PLCB4D630, with potential immunostimulatory and antineoplastic activities.
Upon administration, IKKb-matured, RNA-loaded autologous DCs DCIKKb may elicit a highly
specific cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the
TAAs and driver mutations encoded by the loaded RNA.;
NCI Metathesaurus CUI : CL1642579;
Origin ID : C176747;
UMLS CUI : C5447412;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
