Preferred Label : Pelecopan;
NCIt synonyms : FD Inhibitor BCX9930; Complement Factor D Inhibitor BCX9930; Factor D Inhibitor BCX9930;
NCIt definition : An orally bioavailable inhibitor of complement factor D (FD; CFD), a serine protease
that cleaves complement factor B, with potential complement system inhibiting activity.
Upon oral administration, pelecopan targets, binds to and blocks the activity of FD,
thereby inhibiting the cleavage of complement factor B into Ba and Bb in the alternative
pathway of the complement cascade. This inhibits FD-mediated signaling and the activation
of the alternative complement pathway (ACP), blocks complement-mediated hemolysis
in paroxysmal nocturnal hemoglobinuria (PNH) and prevents ACP-induced tissue damage.
FD plays a key role in the activation of the ACP.;
UNII : JD988C0G6J;
CAS number : 2378380-49-3;
Molecule name : BCX 9930; BCX-9930;
NCI Metathesaurus CUI : CL1642580;
Origin ID : C176745;
UMLS CUI : C5783397;
Semantic type(s)
- concept_is_in_subset
