Preferred Label : Interferon Gamma-primed Human Bone Marrow-derived Mesenchymal Stromal Cells;
NCIt synonyms : Interferon Gamma-primed Human Bone Marrow-derived MSCs; IFN-g-primed MSCs; IFN-g-primed Human Bone Marrow-derived MSCs;
NCIt definition : Human bone marrow-derived mesenchymal stromal cells (MSCs) primed with interferon
gamma (IFN-g), with potential immunomodulatory activity. Upon priming with IFN-g and
the administration of IFN-g-primed human bone marrow-derived MSCs, IFN-g activates
the IFN-g-Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1)
signaling pathway and induces indoleamine 2,3-dioxygenase (IDO) expression in MSCs.
This promotes IDO activity and enhances the inhibition of T-cell proliferation mediated
by MSCs. This may enhance MSC-mediated immunosuppression and prevent graft-versus-host
disease (GvHD).;
NCI Metathesaurus CUI : CL1642573;
Origin ID : C176740;
UMLS CUI : C5447406;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
