NCIt definition : A quassinoid phytochemical isolated from Simaba cedron and other plant species with
potential antineoplastic activity. Chaparrin is a mixture of compounds that includes
flavonoids, antioxidants, and nordihydroguaiaretic acid (NDGA). NDGA is an antioxidant
and lipoxygenase inhibitor that promotes cell differentiation, induces G1 phase cell-cycle
arrest, and causes apoptosis in certain cancer cell lines. (NCI04);