Preferred Label : Peppermint Oil-containing Enteric-coated Microspheres;
NCIt definition : A formulation composed of enteric-coated, sustained-release (SR) microspheres containing
ultrapurified peppermint oil (Mentha piperita), a naturally-occurring carminative
herb containing monoterpene compounds, with potential calming, anti-bacterial, anti-inflammatory,
analgesic and anti-spasmodic activities. Upon oral administration of the peppermint
oil-containing enteric-coated microspheres, the formulation allows for an initial
quick release of peppermint oil in the small intestine and after that it is released
throughout the small intestine over an extended period of time from the individual
microspheres. The L-menthol in this formulation targets and blocks calcium channels
in smooth muscle in the small intestine, thereby producing an anti-spasmodic effect
on the gastrointestinal tract (GI). This allows for relaxation of smooth muscle and
helps calm uncontrolled spasms. This may normalize digestion, decrease pain and discomfort,
prevents cramping, bloating, diarrhea and constipation. L-menthol's kappa opioid agonist
activity may further reduce abdominal pain and cramping. Through its anti-microbial
effect, L-menthol may promote bacterial balance in the small intestine. The anti-inflammatory
activity of L-menthol prevents inflammation associated with gut mucosal barrier disruption.
Additionally, this formulation contains fiber and amino acids, which may further improve
the integrity of the mucosal barrier.;
Drug name : IBgard;
NCI Metathesaurus CUI : CL1642636;
Origin ID : C176629;
UMLS CUI : C5447336;
Semantic type(s)
- concept_is_in_subset
