Preferred Label : STING Agonist-containing PTGFRN-expressing Exosomes CDK002;
NCIt synonyms : STING Agonist-containing Exosomes CDK002; STING Agonist CDK002; exoSTING CDK002;
NCIt definition : Exosomes containing an agonist of the stimulator of interferon genes protein (STING;
transmembrane protein 173; TMEM173) and expressing high levels of the exosome surface
glycoprotein prostaglandin F2 receptor negative regulator (PTGFRN; CD315), with potential
immunoactivating and antineoplastic activities. Upon intratumoral administration,
STING agonist-containing PTGFRN-expressing exosomes CDK002 preferentially targets
and binds to STING on antigen-presenting cells (APCs), specifically monocytes and
M2 macrophages, in the tumor microenvironment (TME) and activates the STING pathway.
This leads to the activation of the innate immune response locally and results in
the production of pro-inflammatory cytokines, including interferons (IFNs), enhances
the cross-presentation of tumor-associated antigens (TAAs) by dendritic cells (DCs),
and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer
cells. STING, a transmembrane protein that activates immune cells in the TME, plays
a key role in the activation of the innate immune system. The exosome-based formulation
may provide targeted anti-tumor immunity while minimizing off-target toxicity, including
the toxic systemic cytokine elevation. PTGFRN, expressed on the surface of the exosome,
facilitates specific uptake in tumor-resident APCs and enhances the APC-mediated systemic
anti-tumor immune response.;
Molecule name : CDK-002; CDK 002;
NCI Metathesaurus CUI : CL1642416;
Origin ID : C176581;
UMLS CUI : C5447315;
Semantic type(s)
- concept_is_in_subset
- has_target
