Preferred Label : STING Agonist MK-2118;
NCIt definition : An agonist of the intracellular innate immune adaptor stimulator of interferon genes
protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating
and antineoplastic activities. Upon intratumoral administration, STING agonist MK-2118
targets and binds to STING and activates the STING pathway in immune cells in the
tumor microenvironment (TME). This leads to the production of pro-inflammatory cytokines,
including interferons (IFNs), enhances the cross-presentation of tumor-associated
antigens (TAAs) by dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated
immune response against cancer cells. STING, a transmembrane protein that activates
immune cells in the TME, plays a key role in the activation of the innate immune system.;
Molecule name : MK-2118; MK 2118;
NCI Metathesaurus CUI : CL1642441;
Origin ID : C176562;
UMLS CUI : C4733596;
Semantic type(s)
- concept_is_in_subset
- has_target
