Preferred Label : Gallium Ga 68 FAP-2286;
NCIt synonyms : Gallium-68-FAP-2286; 68Ga-FAP-2286; Gallium-68 labelled FAP-2286;
NCIt definition : A radioconjugate composed of FAP-2286, a fibroblast activation protein (FAP)-targeted
peptide, attached to a linker and tetraazacyclododecane tetraacetic acid chelator,
conjugated to the radioisotope gallium Ga 68, with potential use as a tracer for FAP-expressing
cancer-associated fibroblasts (CAFs) during positron emission tomography (PET). Upon
administration of gallium Ga 68 FAP-2286, the FAP-2286 moiety targets and binds to
FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected during PET
imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment
(TME).;
NCI Metathesaurus CUI : CL1642513;
Origin ID : C176457;
UMLS CUI : C5447255;
Semantic type(s)
- concept_is_in_subset
- has_target
