NCIt synonyms : Johnson and Johnson COVID-19 Vaccine; Ad26-encoding SARS-CoV-2 Spike Protein Vaccine; Ad26COVS1; Ad26.COV2.S;
NCIt related terms : Johnson & Johnson COVID-19 Vaccine; Ad26.COV2.S (Johnson & Johnson/Janssen);
NCIt definition : A coronavirus vaccine composed of a genetically engineered, replication-incompetent,
adenovirus serotype 26 (Ad26) vector expressing the stabilized pre-fusion spike (S)
protein of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), with
potential immunomodulating and anti-COVID-19 activities. Upon intramuscular administration
of the COVID-19 vaccine Ad26.COV2.S, the Ad26 infects human cells, which produces
SARS-CoV-2 S protein. The released S protein activates the immune system to induce
a humoral and cell-mediated immune response against SARS-CoV-2. This may prevent SARS-CoV-2
infection and inhibit viral replication. S protein, usually found on the surface of
SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.;