Preferred Label : Allogeneic NKG2D-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX101;
NCIt synonyms : IL-15-armored NKG2D Ligands-targeting NKX101; Allogeneic mbIL-15/NKG2D-OX40-CD3zeta-CAR Expressing NKs NKX101;
NCIt definition : A preparation of off-the-shelf (OTS), allogeneic and ex vivo expanded natural killer
cells (NKs) that are engineered to express membrane-bound IL-15 (mbIL15) and a chimeric
antigen receptor (CAR) encoding for human natural-killer group 2, member D receptor
protein (NKG2D; KLRK1; natural killer cell activating receptor group 2D) that is coupled
to the co-stimulatory domain of OX40 (CD134), and to the zeta chain of the TCR/CD3
complex (CD3-zeta; CD3zeta), with potential immunomodulating and antineoplastic activities.
Upon transfusion of the allogeneic NKG2D-OX40-CD3zeta-CAR-mbIL-15-expressing NKs NKX101,
these cells specifically target and bind to tumor cells expressing NKG2D ligands (NKG2DL).
This induces secretion of pro-inflammatory cytokines and results in the lysis of NKG2DL-expressing
tumor cells. In addition, these cells target, bind to and kill NKG2DL-expressing tumor-associated
endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory
T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment
(TME) that express NKG2D ligands. IL-15 is a pro-survival cytokine that potentiates
the immune response against tumor cells. NKG2D ligands are overexpressed in a variety
of cancer cells.;
Molecule name : NKX-101; NKX 101;
NCI Metathesaurus CUI : CL1413428;
Origin ID : C176027;
UMLS CUI : C5446933;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
