Preferred Label : PI3K-delta Inhibitor BGB-10188;
NCIt synonyms : PI3Kdelta Inhibitor BGB-10188;
NCIt definition : An orally available selective inhibitor of the delta isoform of phosphatidylinositol
3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic
activity. Upon oral administration, PI3K-delta inhibitor BGB-10188 selectively binds
to and inhibits PI3K-delta and prevents the activation of the PI3K/AKT signaling pathway.
This decreases proliferation of and induces cell death in PI3K-delta over-expressing
tumor cells. PI3K-delta also plays a key role in the B-cell receptor (BCR) signaling
pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition
of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells,
thereby minimizing serious side effects.;
Molecule name : BGB-10188; BGB 10188;
NCI Metathesaurus CUI : CL1413422;
Origin ID : C175971;
UMLS CUI : C5446896;
Semantic type(s)
- concept_is_in_subset
- has_target
