Preferred Label : TLR7 Agonist JNJ-64794964;
NCIt synonyms : Toll-like Receptor 7 Agonist AL-034;
NCIt definition : An orally bioavailable Toll-like receptor (TLR) 7 agonist, with potential immunostimulating,
antiviral and antitumor activities. Upon oral administration, TLR7 agonist JNJ-64794964
specifically targets, binds to and activates TLR7. This triggers anti-viral and anti-tumor
activities through the activation of cluster of differentiation (CD) 8-positive T
cells, B cells, and innate immune cells including natural killer (NK) cells and macrophages,
secretion of interferon alpha (IFNa), and the production of various pro-inflammatory
and anti-inflammatory cytokines. TLR7 is a member of the TLR family, which plays a
fundamental role in pathogen recognition and activation of innate immunity.;
Molecule name : JNJ 64794964; JNJ-4964; TQ-A3334; JNJ-64794964; JNJ 4964; AL-034; TQ A3334; AL 034;
NCI Metathesaurus CUI : CL1413122;
Origin ID : C175967;
UMLS CUI : C5446892;
Semantic type(s)
- concept_is_in_subset
