Breast Classic Lobular Carcinoma In Situ

Preferred Label : Breast Classic Lobular Carcinoma In Situ;

NCIt synonyms : Breast Classic LCIS;

NCIt definition : Breast lobular carcinoma in situ characterized by the presence of dyscohesive proliferations of type A and/or type B epithelial cells. Type A cells are small cells with uniform hyperchromatic nuclei, whereas type B cells have slightly larger vesicular nuclei, with mild variability in size and shape and with small nucleoli. The cell populations may be mixed in individual proliferations. (WHO 2019);

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1413138;

Details

Origin ID

C175949;

UMLS CUI

C5446877;

Disease excludes abnormal cell
- Ductal Carcinoma Cell [NCIt concept]
- Dysplastic Squamous Cell [NCIt concept]
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Disease may have findings
- Multifocal Lesion [NCIt concept]
Has associated anatomic sites
- Breast [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Breast Lump [NCIt concept]
- Invasive Lesion [NCIt concept]
- Marked Distention of Terminal Duct Lobular Units Present [NCIt concept]
- Mixed Cellular Population [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
- Nuclear Pleomorphism [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Dysplastic Glandular Cell [NCIt concept]
- Lobular Carcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_finding
- Absence of Invasion [NCIt concept]
- Carcinomatous Component Present [NCIt concept]
- Dysplasia [NCIt concept]
- Epithelial Component Present [NCIt concept]
- In Situ Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Severe Dysplasia [NCIt concept]
disease_has_grade
- Grade 3 [NCIt concept]
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Glandular Cell [NCIt concept]
- Terminal Ductal Lobular Unit Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Glandular Epithelium [NCIt concept]
- Mammary Epithelium [NCIt concept]
- Terminal Ductal Lobular Unit [NCIt concept]
disease_has_primary_anatomic_site
- Breast [NCIt concept]
disease_is_stage
- AJCC v6 Stage [NCIt concept]
- AJCC v7 Stage [NCIt concept]
- Stage 0 [NCIt concept]
disease_mapped_to_gene
- CDH1 Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 6q [NCIt concept]
- Loss of Chromosome 16p [NCIt concept]
- Loss of Chromosome 16q [NCIt concept]
- Loss of Chromosome 17p [NCIt concept]
- Loss of Chromosome 22q [NCIt concept]
disease_may_have_molecular_abnormality
- CDH1 Gene Inactivation [NCIt concept]
- Loss of E-cadherin Expression [NCIt concept]
- PIK3CA Gene Mutation [NCIt concept]

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