Preferred Label : Eciskafusp Alfa;
NCIt synonyms : PD-1 Targeted IL-2v Antibody Fusion Protein RO7284755; PD-1-targeted IL-2 Variant Immunocytokine RO7284755; PD-1 Targeted IL2v Cytokine RO7284755; PD1-IL2v RO7284755; PD-1-targeted IL-2 Variant Antibody Fusion Protein RO7284755;
NCIt definition : A recombinant fusion protein comprised of an antibody directed against the human negative
immunoregulatory checkpoint receptor programmed cell death protein 1 (PD-1; PDCD1;
CD279) linked to an engineered, variant form of interleukin-2 (IL-2v), with potential
immunostimulating and antineoplastic activities. Upon administration of eciskafusp
alfa, the antibody moiety specifically targets and binds to PD-1 expressed on tumor-infiltrating
lymphocytes (TILs) and inhibits the PD-1-mediated downregulation of T-cell activation
and proliferation. The IL-2 moiety may stimulate a local immune response and activate
natural killer (NK) cells and cytotoxic T-cells. This may enhance the activity of
neoantigen specific T-cells and potentiates T-cell-mediated immune responses against
tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF)
expressed on T-cells, functions as an immune checkpoint that negatively regulates
T-cell activation and effector function when activated by its ligands, programmed
cell death-1 ligand 1 (PD-L1; B7-H1; CD274) and 2 (PD-L2); it plays an important role
in tumor evasion from host immunity. IL-2v cannot bind to IL-2 receptor-alpha (CD25,
IL2Ra) and does not activate regulatory T-cells (Tregs).;
UNII : XPV3BT6FPY;
CAS number : 2649758-52-9;
Molecule name : RG-6279; RO-7284755; RG 6279; RO 7284755;
NCI Metathesaurus CUI : CL1413142;
Origin ID : C175945;
UMLS CUI : C5908092;
Semantic type(s)
- concept_is_in_subset
