Preferred Label : Personalized Neoantigen Ovarian Cancer Vaccine;
NCIt synonyms : Neoantigen-based Ovarian Cancer Vaccine; Personalized Neoantigen Peptides Ovarian Cancer Vaccine; Neoantigen-based Ovarian Cancer-poly-ICLC Vaccine; NeoVax Ovarian Cancer Vaccine;
NCIt definition : A peptide-based, personalized ovarian cancer therapeutic vaccine consisting of up
to 20 neoantigens and peptides derived from patient-specific ovarian cancer immunogenic
epitopes, combined with the immunostimulant poly-ICLC, with potential immunomodulating
and antineoplastic activities. Upon administration, the personalized neoantigen ovarian
cancer vaccine stimulates the host immune system to mount a cytotoxic T-lymphocyte
(CTL) response against tumor cells expressing the neoantigens, which results in tumor
cell lysis. The adjuvant poly-ICLC, composed of double-stranded RNA molecules of polyinosinic-polycytidylic
acid stabilized with poly L-lysine in carboxymethylcellulose, is a ligand for toll-like
receptor-3 (TLR3) and induces the release of cytokines which may help to boost the
immune response against the selected neoantigens.;
NCI Metathesaurus CUI : CL1413119;
Origin ID : C175904;
UMLS CUI : C5446836;
Semantic type(s)
- concept_is_in_subset
