Preferred Label : Personalized Neoantigen Follicular Lymphoma Vaccine;
NCIt synonyms : Neoantigen-based Follicular Lymphoma Vaccine; Neoantigen-based Follicular Lymphoma-poly-ICLC Vaccine; Neo Vax Follicular Lymphoma Vaccine; NeoVax Follicular Lymphoma Vaccine;
NCIt definition : A peptide-based, personalized follicular lymphoma therapeutic vaccine consisting of
up to 20 neoantigens and peptides derived from patient-specific follicular lymphoma
immunogenic epitopes, combined with the immunostimulant poly-ICLC, with potential
immunomodulating and antineoplastic activities. Upon administration, the personalized
neoantigen follicular lymphoma vaccine stimulates the host immune system to mount
a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens,
which results in tumor cell lysis. The adjuvant poly-ICLC, composed of double-stranded
RNA molecules of polyinosinic-polycytidylic acid stabilized with poly L-lysine in
carboxymethylcellulose, is a ligand for toll-like receptor-3 (TLR3) and induces the
release of cytokines which may help to boost the immune response against the selected
neoantigens.;
NCI Metathesaurus CUI : CL1413081;
Origin ID : C175881;
UMLS CUI : C5446816;
Semantic type(s)
- concept_is_in_subset
