Preferred Label : Vidutolimod;
NCIt synonyms : VLP-encapsulated TLR9 Agonist CMP-001;
NCIt definition : A virus-like particle (VLP) composed of the Qbeta bacteriophage capsid encapsulating
the toll-like receptor 9 (TLR9) agonist G10, an unmethylated CpG-A oligodeoxynucleotide
(ODN), with potential immunostimulating and antineoplastic activities. Upon administration
of vidutolimod, the VLPs are specifically taken up by and release the oligonucleotide
into antigen-presenting cells (APCs), including dendritic cells (DCs). In turn, the
oligonucleotide binds to and activates intracellular TLR9. This stimulates immune
signaling pathways, induces the innate immune system and may promote the immune system
to attack tumor cells. VLPs stimulate the immune system. TLR9, a member of the TLR
family, plays a key role in both pathogen recognition and the activation of innate
immunity.;
UNII : D68OW5RS98;
CAS number : 147063-80-7;
Molecule name : CYT-003; CYT 003; QbG10; ARB-1598; CMP-001;
NCI Metathesaurus CUI : CL1413087;
Origin ID : C175875;
UMLS CUI : C5446810;
Semantic type(s)
- concept_is_in_subset
- has_target
