NCIt definition : An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant
form T790M, with potential antineoplastic activity. Upon administration, befotertinib
specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation,
which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing
tumor cells. Compared to some other EGFR inhibitors, befotertinib may have therapeutic
benefits in tumors with T790M-mediated drug resistance. EGFR, a receptor tyrosine
kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation
and tumor vascularization.;
Semantic type(s)