Preferred Label : Autogene Cevumeran;
NCIt synonyms : Personalized Cancer Vaccine RO7198457; PCV RO7198457;
NCIt definition : An mRNA-based individualized, therapeutic cancer vaccine targeting an unspecified
amount of tumor-associated antigens (TAAs) that are specifically expressed in the
patient's cancer, with potential immunostimulatory and antineoplastic activities.
Upon administration, autogene cevumeran is taken up and translated by antigen presenting
cells (APCs) and the expressed protein is presented via major histocompatibility complex
(MHC) molecules on the surface of the APCs. This leads to an induction of both cytotoxic
T-lymphocyte (CTL)- and memory T-cell-dependent immune responses against cancer cells
expressing the TAA(s).;
UNII : L8HDH9IB06;
CAS number : 2365453-34-3;
Molecule name : BNT 122; RO-7198457; RO 7198457; RG 6180; BNT-122;
NCI Metathesaurus CUI : CL538249;
Origin ID : C175745;
UMLS CUI : C5446707;
Semantic type(s)
- concept_is_in_subset
