Preferred Label : Sodium Thiosulfate Formulation DB-020;
NCIt synonyms : STS Formulation DB-020;
NCIt definition : An injectable sterile viscous solution composed of the thiol-containing reducing agent
sodium thiosulfate (STS) pentahydrate formulated in sodium hyaluronate in sterile
water that can be used to prevent ototoxicity. Upon administration into the ear via
trans tympanic injection, thiosulfate targets and irreversibly binds to cisplatin.
This inactivates cisplatin locally in the cochlea and prevents hearing loss caused
by cisplatin without interfering with cisplatin's anti-cancer activity. As DB-020
can be administered directly to the ear prior to each cycle of chemotherapy, it may
protect the ear from cisplatin's ototoxic effects.;
Molecule name : DB-020; DB 020;
NCI Metathesaurus CUI : CL1412936;
Origin ID : C175594;
UMLS CUI : C5446645;
Semantic type(s)
- concept_is_in_subset
