Preferred Label : IL-15/IL-15 Receptor alpha Heterodimer NIZ985;
NCIt synonyms : IL-15/IL-15Ra Heterodimer NIZ985; hetIL-15 NIZ985;
NCIt definition : A soluble, recombinant human heterodimer composed of the cytokine interleukin (IL)-15
and the IL-15 receptor alpha (IL-15Ra), with potential antineoplastic activity. Upon
subcutaneous administration, the IL-15/IL-15Ra heterodimer (hetIL-15) NIZ985 targets
and binds to interleukin-2 (IL-2)/IL-15 receptor beta/gamma. This activates and increases
the levels of natural killer (NK) cells and memory CD8 T-cells. The memory T-cells
enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates
the immune response against tumor cells. This may increase tumor cell killing and
decrease tumor cell proliferation. IL-15 regulates CD8 T and NK cell development,
activation and proliferation. NIZ985 does not require endogenous IL-15Ra for its activation.;
Molecule name : NIZ 985; NIZ-985;
NCI Metathesaurus CUI : CL1412938;
Origin ID : C175592;
UMLS CUI : C5446643;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
